Wahyong DS-1406AT automatic sampling and dissolution system consists of a 14 cup dissolution device and an automatic sampler. In addition, 12 cups are used for dissolution testing, and the other 2 cups are used for replenishment after sampling. Adopting a fully automatic control system to achieve integrated operations such as automatic dosing, dissolution, and sampling of drugs, achieving precise temperature control, precise sampling, automatic liquid replenishment, and automatic cleaning. This elevates conventional dissolution technology to the optimal level and is highly favored by users. The specific technical features are as follows:
1. Compliance with regulatory requirements
The performance of the instrument fully meets the requirements of domestic and foreign regulations and standards such as USP and ChP, and Guiding Principles for Mechanical Validation of Drug Dissolution Meters.
2. Coaxial design using paddle/basket method
①Coaxial design of paddle and basket, the same host can switch between paddle method, basket method, rotary cylinder method, paddle disc method, small cup method, and immersion pool method;
②Add sealing rings at the coaxial connection to ensure a tighter connection and no looseness during long-term operation of the shaft.
③A common transmission system that can connect interchangeable rotating baskets, blades, and small paddles. After the initial positioning of the height, there is no need to adjust it again, and switching is extremely convenient. Combined with high-precision machining technology, it ensures that the swing of the shaft is ≤ ± 0.2mm.
3. Accurate temperature control
The instrument is equipped with handheld and fixed lifting high-precision electronic temperature measuring probes, which are flexible and convenient for monitoring the temperature of each dissolution cup medium. The temperature control accuracy is ≤ ± 0.2 ℃.
4. Automatic center positioning dissolution cup
①The integrated dissolution cup features automatic center positioning and orientation, automatic locking, and extremely high accuracy to minimize positional variability while improving uniformity.
②Change in centrality of the dissolution cup after unloading 1000 times ≤ 0.3mm.
Change in the centrality of the dissolution cup after unloading 1000 times
5. Automatic lifting system
①The automatic lifting platform keeps the machine head in a horizontal state for a long time, ensuring that the verticality and coaxiality of the dissolution meter shaft remain unchanged for a long time.
②Patented design ensures continuous and stable drug dissolution experiments, reducing the risk of drug dissolution differences caused by changes in instrument mechanical properties.
③The top of the dissolution meter's rotating shaft is fixed with a double bearing design, ensuring that the shaft is always in a vertical and coaxial state during long-term operation, ensuring the stability of the experiment, and achieving the best coaxiality level in the industry.
6. Design of dual drive shaft system
①12 channels are divided into 6+6 zones for control, which can achieve dual solvent and dual speed dissolution tests, with a speed error of ≤ ± 0.3rpm.
②Users can freely choose 6 or 12 cups of dissolution test according to their preferences.
③The sampler adopts a 6+6 dual group design, which can achieve free grouping sampling and meet the requirements of different experimental conditions.
④12 channel independent pipeline system for precise sampling.
7. Low head design
①Improve the sealing of the dissolution cup and reduce the evaporation of the dissolution medium during the dissolution test process.
②Low head design, shortening the length of the dissolution mixing propeller shaft, reducing swing, and improving experimental stability.
8. Automatic synchronous dosing device
①The integrated automatic dosing and anti evaporation cover device can achieve automatic and manual synchronized dosing of tablets, capsules, granules, and powders.
②The design of a quick detachable doser allows for the complete cleaning of the doser in just 30 seconds, avoiding drug residue.
9. Online secondary filter
①Manual or automatic filter replacement, excellent flow path design allows the filter to fully adsorb.
②It Can be paired with an automatic membrane changer, making filter replacement more convenient.
③Sampling to liquid vials, efficient and time-saving.
④It can be connected to a commercially available 0.22/0.45um filter, and the sample can be used for HPLC without further filtration during sampling.
10. Precision Mechanical Verification System
①The Wahyong 260-DS mechanical certification system consists of various mathematical detection instruments that have passed third-party metrological verification, combined with Huarong Instrument 260-DS workstation software.
②The 260-DS mechanical certification system can bring higher analytical accuracy and efficiency to customers. At the same time, customers can freely increase the frequency of certification to achieve higher integrity.
③The 260-DS mechanical certification system is compatible with all open dissolution meters, including convenient fixing clips and adjustment capabilities for different specifications of dissolution cups.
④After installation, the data of the detection instrument will be transmitted in real-time to the computer version of the 260-DS workstation software using Bluetooth communication. The quantitative values of each parameter will be recorded and displayed in real-time through the software.
⑤We can Provide 3Q verification services (IQ, OQ, PQ).
